1. Retina. 2015 Dec;35(12):e77-8. doi: 10.1097/IAE.0000000000000890.

Correspondence.

Arora S(1), Arora P, Arora R, Ghosh B.

Author information: 
(1)*Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India
†Department of Laboratory Medicine, All India Institute of Medical Sciences, New 
Delhi, India.

PMID: 26584442   [PubMed - in process]


2. Retina. 2015 Dec;35(12):e76-7. doi: 10.1097/IAE.0000000000000888.

Reply.

Wong RK(1), Tsui I.

Author information: 
(1)Retina Division, Department of Ophthalmology, Jules Stein Eye Institute,
University of California, Los Angeles, CA.

PMID: 26584441   [PubMed - in process]


3. Retina. 2015 Dec;35(12):e76. doi: 10.1097/IAE.0000000000000889.

Correspondence.

Mayor R(1), Dave P, Venkatesh R, Singh S, Agarwal M, Paul L, Gurav P.

Author information: 
(1)Department of Vitreoretina, Dr. Shroffs Charity Eye Hospital, Delhi, India.

PMID: 26584440   [PubMed - in process]


4. Retina. 2015 Dec;35(12):2664-8. doi: 10.1097/IAE.0000000000000899.

ANALYSIS OF A CONFOCAL SCANNING LASER OPHTHALMOSCOPE NONCONTACT ULTRA-WIDE FIELD 
LENS SYSTEM IN RETINAL AND CHOROIDAL DISEASE.

Espina MP(1), Arcinue CA, Ma F, Camacho N, Bartsch DU, Freeman WR.

Author information: 
(1)Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Institute,
University of California San Diego, La Jolla, California.

PMID: 26584439   [PubMed - in process]


5. Retina. 2015 Dec;35(12):2660-3. doi: 10.1097/IAE.0000000000000883.

MODIFIED CURVED ASPIRATION CANNULAS AND END-GRIPPING FORCEPS FOR 25-GAUGE
VITRECTOMY ON HIGHLY MYOPIC EYES.

Lytvynchuk LM(1), Sergiienko A, Richard G.

Author information: 
(1)*Department of Ophthalmology, University Medical Center Hamburg-Eppendorf,
Hamburg, Germany; †Professor Sergienko Eye Clinic, Vinnytsia, Ukraine; ‡Karl
Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria; and
§Department of Ophthalmology, Rudolf Foundation Hospital, Vienna, Austria.

PMID: 26584438   [PubMed - in process]


6. Retina. 2015 Nov 18. [Epub ahead of print]

WIDEFIELD FLUORESCEIN ANGIOGRAPHY IN PATIENTS WITHOUT PERIPHERAL DISEASE: A Study
of Normal Peripheral Findings.

Shah AR(1), Abbey AM, Yonekawa Y, Khandan S, Wolfe JD, Trese MT, Williams GA,
Capone A Jr.

Author information: 
(1)*Associated Retinal Consultants, Royal Oak, Michigan; and †Department of
Ophthalmology, Oakland University William Beaumont School of Medicine, Beaumont
Eye Institute, Royal Oak, Michigan.

PURPOSE: Widefield photography and angiography provide access up to 200-degrees
of the retinal periphery. The range of normal peripheral findings has not been
characterized, yet is relevant to studies addressing putative peripheral retinal 
vascular pathology.
METHODS: This study was an observational retrospective cohort study. Adult
patients with epiretinal membrane or choroidal nevi who underwent imaging with
Optos 200 MA/200Tx were included. Dye transit times, peripheral arteriovenous
shunting, presence of vessels crossing the horizontal raphe, right angle vessels,
terminal networks, absence of capillary detail, ground glass hyperfluorescence,
peripheral drusen, and microaneurysms were evaluated.
RESULTS: Fifty-eight eyes of 31 patients met inclusion criteria. Mean peripheral 
arterial filling time was 8.65 ± 2.54 seconds (range 3-15 seconds). One or more
peripheral anomalies were noted in all patients (P < 0.01). The prevalences of
findings were: arteriovenous shunting (0.00%), vessels crossing the horizontal
raphe (44.83%), right angle vessels (70.69%), terminal networks (77.59%), absence
of capillary detail (98.28%), ground glass hyperfluorescence (87.93%), drusen
(34.48%), and microaneurysms (41.38%).
CONCLUSION: There was a high prevalence of peripheral vascular anatomic
variations in eyes expected to have normal peripheral retinal vasculature. These 
findings may provide a reference for future studies addressing putative
pathologic peripheral angiographic findings.

PMID: 26583312   [PubMed - as supplied by publisher]


7. Retina. 2015 Nov 18. [Epub ahead of print]

OPTIC NERVE INFILTRATION BY RETINOBLASTOMA: Predictive Clinical Features and
Outcome.

Kaliki S(1), Tahiliani P, Mishra DK, Srinivasan V, Ali MH, Reddy VA.

Author information: 
(1)*Operation Eyesight Universal Institute for Eye Cancer; †Ophthalmic Pathology 
Service; and ‡Center for Clinical Epidemiology and Biostatistics, LV Prasad Eye
Institute, Hyderabad, India.

PURPOSE: To identify the clinical features predictive of any optic nerve
infiltration and postlaminar optic nerve infiltration by retinoblastoma on
histopathology and to report the outcome (metastasis and death) in these
patients.
METHODS: Retrospective study.
RESULTS: Of the 403 patients who underwent primary enucleation for
retinoblastoma, 196 patients had optic nerve tumor infiltration (Group 1) and 207
patients had no evidence of optic nerve tumor infiltration (Group 2). Group 1
included patients with prelaminar (n = 47; 24%), laminar (n = 74; 38%), and
postlaminar tumor infiltration with or without involving optic nerve transection 
(n = 74; 38%). Comparing Group 1 and Group 2, the patients in Group 1 had
prolonged duration of symptoms (>6 months) (16% vs. 8%; P = 0.02) and were
associated with no vision at presentation (23% vs. 10%; P = 0.01), higher rates
of secondary glaucoma (42% vs. 12%; P < 0.0001), iris neovascularization (39% vs.
23%; P < 0.001), and larger tumors (mean tumor thickness, 12.8 mm vs. 12 mm; P = 
0.0001). There was a higher prevalence of metastasis in Group 1 than in Group 2
(4% vs. 0%; P = 0.006). On multivariate analysis, clinical features predictive of
any optic nerve tumor infiltration secondary glaucoma (hazard ratio = 5.38; P <
0.001) and those predictive of postlaminar optic nerve tumor infiltration
included iris neovascularization (hazard ratio = 2.66; P = 0.001) and secondary
glaucoma (hazard ratio = 3.13; P < 0.001).
CONCLUSION: In this study, clinical features predictive of any optic nerve tumor 
infiltration included secondary glaucoma and those predictive of postlaminar
optic nerve tumor infiltration included iris neovascularization and secondary
glaucoma. Despite adjuvant treatment in those with postlaminar optic nerve tumor 
infiltration, metastasis occurred in 8% of patients.

PMID: 26583311   [PubMed - as supplied by publisher]


8. Retina. 2015 Nov 18. [Epub ahead of print]

CORRELATION OF VISUAL ACUITY WITH FIBROTIC SCAR LOCATION IN TREATED NEOVASCULAR
AGE-RELATED MACULAR DEGENERATION EYES.

Ryu CL(1), Al-Humaid S, Rampakakis E, Galic IJ, Chen JC.

Author information: 
(1)*Department of Ophthalmology, McGill University, Montreal, Quebec, Canada; and
†Scientific Affairs, JSS Medical Research, Montreal, Quebec, Canada.

PURPOSE: To determine whether the optical coherence tomography location of a
subfoveal fibrovascular scar is correlated with visual outcome in eyes
successfully treated with antivascular endothelial growth factor agents for
neovascular age-related macular degeneration.
METHODS: Fifty-six eyes from 56 patients with a subfoveal disciform scar after
antivascular endothelial growth factor treatment were included. The initial and
final visual acuity, fluorescein angiography, and spectral domain optical
coherence tomography scar characteristics were retrospectively reviewed.
RESULTS: Thirty-five of 56 eyes (62.5%) were classified as having entirely
subretinal pigment epithelial (sub-RPE) scars, and 21 eyes (37.5%) had subretinal
component scars. Mean initial visual acuity was similar between sub-RPE and
subretinal scars (20/100 vs. 20/125, P = 0.517); mean final visual acuity was
better in the sub-RPE scar group (20/60 vs. 20/200, P = 0.001). Eyes with sub-RPE
scar had better preservation of the external limiting membrane, ellipsoid layer, 
and retinal thickness (P < 0.001, P = 0.017, P = 0.004, respectively) than
subretinal component scar eyes. There was no difference between the groups in
scar thickness or scar area (P = 0.707, P = 0.186, respectively).
CONCLUSION: Sub-RPE location of subfoveal scarring in eyes treated for
neovascular age-related macular degeneration is associated with better
preservation of outer retinal structures and better vision, when compared with a 
subretinal scar.

PMID: 26583310   [PubMed - as supplied by publisher]


9. Retina. 2015 Nov 18. [Epub ahead of print]

RANIBIZUMAB FOR DIABETIC MACULAR EDEMA REFRACTORY TO MULTIPLE PRIOR TREATMENTS.

Ciulla TA(1), Hussain RM, Ciulla LM, Sink B, Harris A.

Author information: 
(1)*Retina Service, Midwest Eye Institute, Indianapolis, Indiana; and †Department
of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana.

PURPOSE: Diabetic macular edema can be refractory to multiple treatment
modalities. Although there have been anecdotal reports of ranibizumab showing
efficacy when other modalities provided limited benefit, little has been
published on treatment for refractory diabetic macular edema. This study sought
to investigate this observation further.
METHODS: Retrospective chart review.
RESULTS: Thirty-three eyes of 22 patients with refractory diabetic macular edema 
were treated with 0.3 mg intravitreal ranibizumab. This group of eyes received an
average of 5.1 prior treatments (macular laser, intravitreal bevacizumab,
triamcinolone acetonide, or dexamethasone implant). The mean best corrected
visual acuity before the initial ranibizumab injection was 20/110 and the mean
central subfield thickness was 384 μm. After 7 visits over an average of 48
weeks, during which an average of 6 ranibizumab injections were administered, the
mean visual acuity improved to 20/90 and the mean central subfield thickness
improved to 335 μm. Both central subfield thickness and best corrected visual
acuity improved with number of days of follow-up in a statistically significant
fashion (P < 0.01). Similarly, both central subfield thickness and visual acuity 
improved with number of ranibizumab injections in a linear fashion, but this was 
not statistically significant.
CONCLUSION: Ranibizumab can improve diabetic macular edema refractory to prior
treatments of laser photocoagulation, intravitreal triamcinolone acetonide, and
bevacizumab.

PMID: 26583309   [PubMed - as supplied by publisher]


10. Retina. 2015 Nov 18. [Epub ahead of print]

CHOROIDAL THICKNESS IN INFANTS WITH RETINOPATHY OF PREMATURITY.

Erol MK(1), Coban DT, Ozdemir O, Dogan B, Tunay ZO, Bulut M.

Author information: 
(1)*Antalya Training and Research Hospital, Ophthalmology Department, Antalya,
Turkey; and †Zekai Tahir Burak Women Health Training and Research Hospital,
Ophthalmology Department, Ankara, Turkey.

PURPOSE: To evaluate choroidal thickness in premature infants and its
relationship with stage of retinopathy of prematurity (ROP) using spectral domain
optical coherence tomography (SD-OCT).
METHODS: Spectral domain optical coherence tomography imaging for measuring
subfoveal choroidal thickness was performed for 80 premature infants. Subfoveal
choroidal thickness was defined as the distance from the hyperreflective line of 
the outermost retinal pigment epithelium (RPE) to the innermost hyperreflective
line of the choroidoscleral junction. Each measurement was performed at the
central fovea (CF) and 0.75 mm to 1.5 mm nasal (N1 and N2) and temporal (T1 and
T2) to the fovea. Subfoveal choroidal thickness and grading of cystoid macular
edema (CME) were analyzed statistically.
RESULTS: Choroidal thickness of CF was found to be significantly greater than
nasal (N1 and N2) and temporal (T1 and T2) choroidal thickness (P < 0.05). There 
was no significant relationship between stage of ROP and nasal (N1 and N2)
choroidal thickness (P = 0.057, P = 0.282, respectively). However, CF and
temporal (T1 and T2) choroidal thickness was found to be significantly lower at a
higher stage of ROP (P = 0.005, P = 0.01 and P = 0.001). No significant
relationship was found between subfoveal choroidal thickness and the grades of
cystoid macular edema (P > 0.05). The choroidal thickness of CF was found to be
correlated with birth weight (r = 0.267, P = 0.017) but not birth week (r =
0.140, P = 0.217). Maximum stage of ROP was found to be negatively correlated
with choroidal thickness, at N1, T1, and T2 (r < -0.250, P < 0.02).
CONCLUSION: The subfoveal choroid in premature infants can be effectively
evaluated using a portable SD-OCT device. Choroidal thickness gets thinner with
the severity of ROP and the decrease is more prominent at the central and
temporal location. Cystoid macular edema is not correlated with choroidal
thickness in premature infants.This is an open-access article distributed under
the terms of the Creative Commons Attribution-Non Commercial-No Derivatives
License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work 
provided it is properly cited. The work cannot be changed in any way or used
commercially.

PMID: 26583308   [PubMed - as supplied by publisher]


11. Retina. 2015 Nov 18. [Epub ahead of print]

COMPARISON OF MANUAL AND SEMIAUTOMATED FUNDUS AUTOFLUORESCENCE ANALYSIS OF
MACULAR ATROPHY IN STARGARDT DISEASE PHENOTYPE.

Kuehlewein L(1), Hariri AH, Ho A, Dustin L, Wolfson Y, Strauss RW, Scholl HP,
Sadda SR.

Author information: 
(1)*Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California;
†Department of Ophthalmology, David Geffen School of Medicine, University of
California, Los Angeles, California; ‡Department of Preventive Medicine, Keck
School of Medicine, University of Southern California, Los Angeles, California;
§Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore,
Maryland; and ¶Department of Ophthalmology, Medical University Graz, Graz,
Austria.

PURPOSE: To evaluate manual and semiautomated grading techniques for assessing
decreased fundus autofluorescence (DAF) in patients with Stargardt disease
phenotype.
METHODS: Certified reading center graders performed manual and semiautomated
(region finder-based) grading of confocal scanning laser ophthalmoscopy (cSLO)
fundus autofluorescence (FAF) images for 41 eyes of 22 patients. Lesion types
were defined based on the black level and sharpness of the border: definite
decreased autofluorescence (DDAF), well, and poorly demarcated questionably
decreased autofluorescence (WDQDAF, PDQDAF). Agreement in grading between the two
methods and inter- and intra-grader agreement was assessed by kappa coefficients 
(κ) and intraclass correlation coefficients (ICC).
RESULTS: The mean ± standard deviation (SD) area was 3.07 ± 3.02 mm for DDAF (n =
31), 1.53 ± 1.52 mm for WDQDAF (n = 9), and 6.94 ± 10.06 mm for PDQDAF (n = 17). 
The mean ± SD absolute difference in area between manual and semiautomated
grading was 0.26 ± 0.28 mm for DDAF, 0.20 ± 0.26 mm for WDQDAF, and 4.05 ± 8.32
mm for PDQDAF. The ICC (95% confidence interval) for method comparison was 0.992 
(0.984-0.996) for DDAF, 0.976 (0.922-0.993) for WDQDAF, and 0.648 (0.306-0.842)
for PDQDAF. Inter- and intra-grader agreement in manual and semiautomated
quantitative grading was better for DDAF (0.981-0.996) and WDQDAF (0.995-0.999)
than for PDQDAF (0.715-0.993).
CONCLUSION: Manual and semiautomated grading methods showed similar levels of
reproducibility for assessing areas of decreased autofluorescence in patients
with Stargardt disease phenotype. Excellent agreement and reproducibility were
observed for well demarcated lesions.

PMID: 26583307   [PubMed - as supplied by publisher]


12. Retina. 2015 Nov 13. [Epub ahead of print]

Reply.

Pichi F(1), Nucci P, Srivastava SK.

Author information: 
(1)*Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, Ohio †San
Giuseppe Hospital, University Eye Clinic, Milan, Italy.

PMID: 26579791   [PubMed - as supplied by publisher]


13. Retina. 2015 Nov 13. [Epub ahead of print]

577-NM YELLOW LASER PHOTOCOAGULATION FOR COATS DISEASE.

Levinson JD(1), Hubbard GB 3rd.

Author information: 
(1)Department of Ophthalmology, Emory University, Atlanta, Georgia.

PURPOSE: To describe the outcomes of children with Coats disease treated with
577-nm yellow laser indirect ophthalmoscopy.
METHODS: A retrospective consecutive case series of pediatric patients with Coats
disease treated at a single institution between 2011 and 2014. Laser indirect
ophthalmoscopy was performed under anesthesia. Full treatment was defined as
complete ablation of all visible telangiectasias and resolution of subretinal
fluid. No patients were treated with cryotherapy or bevacizumab.
RESULTS: Seventeen eyes of 16 patients were consecutively treated. At the time of
diagnosis, the eye was classified as Stage 1 (telangiectasias only) in 1 case,
Stage 2A (extra-foveal exudation) in 2 cases, Stage 2B (fovea-involving
exudation) in 6 cases, Stage 3A1 (extra-foveal exudative retinal detachment) in 2
cases, Stage 3A2 (subtotal foveal-involving detachment) in 1 case, and Stage 3B
(total exudative retinal detachment) in 5 cases. The mean age at initial
treatment was 71.2 months. Mean length of follow-up was 20.8 months (median 18.5 
months, range 3.7-37.3 months). Patients underwent an average of 2.5 laser
treatments. Sixteen of 17 eyes achieved full treatment (94.1%) with a mean
time-to-full-treatment of 11.2 months. One eye developed glaucoma and end-stage
disease.
CONCLUSION: 577-nm yellow wavelength laser indirect ophthalmoscopy is an
effective treatment for Coats disease including cases of exudative retinal
detachment.

PMID: 26579790   [PubMed - as supplied by publisher]


14. Retina. 2015 Nov 13. [Epub ahead of print]

Correspondence.

Denniston AK(1), Keane PA.

Author information: 
(1)*Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS
Foundation Trust, Birmingham, United Kingdom †Centre for Translational
Inflammation Research, College of Medical and Dental Sciences, University of
Birmingham, Birmingham, United Kingdom ‡NIHR Biomedical Research Centre for
Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of 
Ophthalmology, United Kingdom.

PMID: 26579789   [PubMed - as supplied by publisher]


15. Retina. 2015 Nov 13. [Epub ahead of print]

25-GAUGE PARS PLANA VITRECTOMY AND SF6 GAS FOR THE REPAIR OF PRIMARY INFERIOR
RHEGMATOGENOUS RETINAL DETACHMENT.

Duvdevan N(1), Mimouni M, Feigin E, Barak Y.

Author information: 
(1)Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.

PURPOSE: To compare anatomical and functional outcomes of 25-gauge pars plana
vitrectomy (PPV) and sulfur hexafluoride gas between inferior and superior
rhegmatogenous retinal detachment (RRD).
METHODS: A retrospective cohort study of patients with RRD who underwent 25-gauge
PPV. Group A consisted of patients with an identified inferior retinal break (4-8
o'clock hours). Group B consisted of patients with an identified superior retinal
break.
RESULTS: Overall, 59 eyes of 59 patients with a mean age of 60.0 ± 12.3 years
were included, with 57.6% being males; 25 with inferior breaks (Group A) and 34
with superior breaks (Group B). The mean follow-up time was 4 months (range 2-16 
months). Single-surgery anatomical success was achieved in 96% (24/25) of Group A
and 82.4% (28/34) of Group B patients (P = 0.22) with final anatomical success
achieved in all cases. In regression analysis, break location (superior versus
inferior) did not significantly account for the variation in single-surgery
success or visual outcomes.
CONCLUSION: Favorable results were achieved using 25-gauge vitrectomy and sulfur 
hexafluoride gas for primary RRD treatment. No differences in anatomical and
functional success rates were observed between inferior and superior retinal
break-associated RRD.

PMID: 26579788   [PubMed - as supplied by publisher]


16. Retina. 2015 Nov 13. [Epub ahead of print]

NUTRITIONAL SUPPLEMENTATION IN AGE-RELATED MACULAR DEGENERATION.

Parodi MB(1), Zucchiatti I, Cicinelli MV, Cascavilla ML, Bandello F.

Author information: 
(1)Department of Ophthalmology, University Vita-Salute, San Raffaele Hospital,
Milan, Italy.

PURPOSE: To evaluate the rate of adherence to prescribed nutritional
supplementation in patients affected by age-related macular degeneration, in an
Italian tertiary referral tertiary center.
METHODS: Patients with age-related macular degeneration, age-related eye disease 
study Categories 3 and 4, were recruited and underwent an 11-item questionnaire.
RESULTS: The study included a total of 193 patients meeting the age-related eye
disease study nutritional supplementation criteria (174 patients with age-related
eye disease study Category 4 and 19 with Category 3). Seventy-seven (40%) were
taking oral supplementation, 70 of whom (90%) 1 tablet/day. Oral supplementation 
was recommended by the personal ophthalmologist in 85 patients (44%), including
all those currently receiving it. Eight patients of 85 (9.4%) rejected
supplementation despite it being recommended, mostly because they were already
taking other medicines. Ninety-four patients (48%) claimed they had not received 
any information from their ophthalmologist.
CONCLUSION: Our data reveal that Italian patients with age-related eye disease
study Categories 3 and 4 have a low adherence to nutritional supplementation. In 
65% of cases, patients were not adequately informed by their ophthalmologist of
the potential benefits of oral supplementation for age-related macular
degeneration; indeed, 108 patients (56%) were not even aware such nutritional
treatments are available. Ophthalmologists should be aware of the importance of
giving advice to persons with age-related macular degeneration regarding the
benefits of oral supplements.

PMID: 26579787   [PubMed - as supplied by publisher]


17. Retina. 2015 Nov 11. [Epub ahead of print]

REDUCTION OF VITREOUS PROSTAGLANDIN E2 LEVELS AFTER TOPICAL ADMINISTRATION OF
INDOMETHACIN 0.5%, BROMFENAC 0.09%, AND NEPAFENAC 0.1.

Russo A(1), Morescalchi F, Vezzoli S, Bernini M, Turano R, Costagliola C, De
Ferrari F, Semeraro F.

Author information: 
(1)*Department of Medical and Surgical Specialties, Radiological Sciences and
Public Health, University of Brescia, Brescia, Italy; †Department of Medical and 
Surgical Specialties, Radiological Sciences and Public Health, Section of Legal
Medicine, University of Brescia, Brescia, Italy; and ‡Department of Medicine and 
Health Sciences, University of Molise, Campobasso, Italy.

PURPOSE: To assess vitreous concentrations of nonsteroidal anti-inflammatory
drugs (NSAIDs) and prostaglandin E2 (PGE2) in patients treated with NSAIDs before
vitrectomy for macular pucker.
METHODS: A prospective, investigator-masked, randomized study was performed in 64
patients scheduled to undergo vitrectomy. The patients were randomized 1:1:1:1 to
receive indomethacin 0.5%, bromfenac 0.09%, nepafenac 0.1%, or placebo three
times a day. NSAIDs and PGE2 levels were evaluated in vitreous samples collected 
at the beginning of surgery.
RESULTS: Mean (SD) vitreous concentrations of the study drugs were 503.13 (241.1)
pg/mL for indomethacin, 302.5 (91.03) pg/mL for bromfenac, and 284.38 (128.2)
pg/mL for nepafenac. Mean (SD) vitreous PGE2 levels were 247.9 (140.9) pg/mL for 
indomethacin, 322.12 (228.1) pg/mL for bromfenac, 448.8 (261.1) pg/mL for
nepafenac, and 1,133 (323.9) pg/mL for placebo. All three NSAIDs reduced vitreous
PGE2 levels to a statistically significant extent, without a significant
difference among them.
CONCLUSION: All assessed NSAIDs penetrated the vitreous and lowered basal PGE2
levels. A greater penetration was associated with pseudophakic eyes. The
important inhibition of prostaglandins in the retina may have a clinical effect
on the management of inflammatory retina diseases.

PMID: 26562569   [PubMed - as supplied by publisher]


18. Retina. 2015 Nov 11. [Epub ahead of print]

POSTOPERATIVE POSITIONING IN MACULAR HOLE SURGERY: An Objective Evaluation of
Nonsupine Positioning and the Effect of the "Tennis Ball Technique".

Forsaa VA(1), Krohn J.

Author information: 
(1)*Department of Ophthalmology, Stavanger University Hospital, Stavanger,
Norway; †Department of Clinical Medicine, Section of Ophthalmology, University of
Bergen, Bergen, Norway; and ‡Department of Ophthalmology, Haukeland University
Hospital, Bergen, Norway.

PURPOSE: To objectively evaluate patients' compliance with a nonsupine
positioning (NSP) regimen after macular hole surgery and to investigate whether
supine positioning time during the first postoperative nights is reduced when a
tennis ball is mounted onto the back of the nightshirt.
METHODS: A "position monitoring device" capable of recording the time the head is
kept in a supine position was attached to the patient's forehead. In a
randomized, controlled, crossover study, the accumulated time each patient spent 
in a supine position was recorded during two consecutive postoperative nights,
both when the "tennis ball technique" (TBT) was used and when it was not,
respectively.
RESULTS: The study included 40 participants. A mean supine time of 14 minutes and
47 seconds was registered with the NSP regimen. When applying the TBT, the mean
supine time was significantly reduced to 4 minutes and 24 seconds (P = 0.01).
Seven "noncompliant" participants with >30 minutes supine time without TBT had
the most marked reduction in supine time from a mean of 63 minutes and 2 seconds,
to 3 minutes and 46 seconds, with TBT (P = 0.02).
CONCLUSION: During an NSP regimen, patients generally maintain a high level of
compliance after macular hole surgery. The TBT further improves their compliance 
significantly.

PMID: 26562568   [PubMed - as supplied by publisher]


19. Retina. 2015 Nov 11. [Epub ahead of print]

Video Angiography of Cilioretinal Artery Infarction in Central Retinal Vein
Occlusion.

Nicholson L(1), Bizrah M, Hussain B, Sivaprasad S.

Author information: 
(1)*Medical Retina Department, Moorfields Eye Hospital, London, United Kingdom;
and †Moorfields Eye Hospital, London, United Kingdom.

PMID: 26562567   [PubMed - as supplied by publisher]


20. Retina. 2015 Nov 11. [Epub ahead of print]

SILICONE OIL BARRIER SUTURES IN APHAKIC EYES WITH IRIS DEFECTS.

Yüksel K(1), Pekel G, Alagöz N, Alagöz C, Baz Ö, Yazc AT.

Author information: 
(1)*Beyoglu Eye Training and Research Hospital, Eye Clinic, Istanbul, Turkey; and
†Department of Ophthalmology, Pamukkale University, Denizli, Turkey.

PURPOSE: To evaluate the efficacy and safety of silicone oil barrier sutures in
aphakic eyes with iris defects.
METHODS: Sixteen aphakic and iris-defective eyes of 16 patients who underwent a
pars plana vitrectomy procedure with silicone oil tamponade because of retinal
detachment were included in this retrospective study. Silicone oil barrier
sutures were placed as a grid pattern within the plane of the previous iris after
vitrectomy and before silicone oil injection.
RESULTS: The mean follow-up time after silicone oil barrier suture operations was
12.0 ± 6.8 months. Silicone oil was present in the anterior chamber in five eyes 
(31%) at the last visit. These eyes also had hypotony, band keratopathy, and
anterior proliferative vitreoretinopathy.
CONCLUSION: In this study, silicone oil barrier sutures were proven to be safe
and effective in preventing silicone oil-corneal endothelium touch in aphakic
eyes with iris defects, unless hypotony was present because of anterior
proliferative vitreoretinopathy.

PMID: 26562566   [PubMed - as supplied by publisher]


21. Retina. 2015 Nov 11. [Epub ahead of print]

RETINAL MORPHOMETRY CHANGES MEASURED WITH SPECTRAL DOMAIN-OPTICAL COHERENCE
TOMOGRAPHY AFTER PAN-RETINAL PHOTOCOAGULATION IN PATIENTS WITH PROLIFERATIVE
DIABETIC RETINOPATHY.

Mitsch C(1), Pemp B, Kriechbaum K, Bolz M, Scholda C, Schmidt-Erfurth U.

Author information: 
(1)*Department of Ophthalmology, Medical University of Vienna, Vienna, Austria;
and †Department of Ophthalmology, General Hospital of Linz, Austria.

PURPOSE: To identify the effects of pan-retinal laser treatment on the integrity 
of neurosensory retinal layers.
METHODS: Patients were examined with fluorescence angiography after a
standardized examination for diabetic retinopathy and a peripapillary ring scan
with spectral domain optical coherence tomography. A single-session pan-retinal
photocoagulation was performed using the PASCAL pattern scanning argon laser
applying a minimum of 1,500 spots. Optical coherence tomography was evaluated
more than 6 months.
RESULTS: Eighteen eyes of 12 consecutive patients with new onset, treatment-naive
proliferative diabetic retinopathy secondary to diabetes Type 2 were treated and 
retinal optical coherence tomography morphology evaluated. Retinal nerve fiber
layer thickness increased statistically significantly from baseline to week 1,
when it reached its peak. The combined thickness of the outer plexiform and the
inner nuclear layers and the combined thickness of the inner plexiform and the
ganglion cell layers showed no relevant changes. The combined thickness of the
retinal pigment epithelium and the photoreceptor cell layers decreased at month 1
followed by a steady increase in thickness, which remained below baseline values 
over time.
CONCLUSION: Pan-retinal photocoagulation in proliferative diabetic retinopathy
leads to a slowly reversible, marked biological response with statistically
significant morphometric changes detected by spectral domain optical coherence
tomography. Swelling of the retinal nerve fiber and outer nuclear layers induce
an increase in peripapillary total retinal thickness. Simultaneously, the
photoreceptor and retinal pigment epithelium layers decrease in thickness. These 
changes indicate diffuse retinal inflammation after pan-retinal laser therapy.

PMID: 26562565   [PubMed - as supplied by publisher]


22. Retina. 2015 Nov 11. [Epub ahead of print]

ENDOSCOPY-ASSISTED VITRECTOMY AND MEMBRANE DISSECTION OF ANTERIOR PROLIFERATIVE
VITREORETINOPATHY FOR CHRONIC HYPOTONY AFTER PREVIOUS RETINAL DETACHMENT REPAIR.

Lee GD(1), Goldberg RA, Heier JS.

Author information: 
(1)*New England Eye Center, Tufts Medical Center, Boston, Massachusetts; †Bay
Area Retina Associates, Walnut Creek, California; and ‡Retina Service, Ophthalmic
Consultants of Boston, Boston, Massachusetts.

PURPOSE: To review 6-month outcomes for patients with hypotony secondary to
anterior proliferative vitreoretinopathy after previous retinal detachment repair
who were treated with endoscopic vitrectomy and anterior membrane dissection.
METHODS: Retrospective review. All individuals underwent endoscopic vitrectomy
with removal of anterior proliferative vitreoretinopathy involving the ciliary
body. Outcome measurements included intraocular pressure (IOP), visual acuity,
and development of phthisis bulbi.
RESULTS: Fifteen eyes of 15 patients had an average of 4.5 previous intraocular
surgeries (range 1-8). Forty Percent of eyes had silicone oil at the time of
endoscopic surgery. Six months postoperatively, 4 eyes had IOP >11 mmHg while 11 
had IOP <6 mmHg. The nonresponder group was older in age, had more previous
intraocular surgeries, and a lower preoperative IOP. There were no differences in
visual acuity or the development of prephthisis at any point. No eyes underwent
enucleation or evisceration.
CONCLUSION: Endoscopy-assisted vitrectomy with removal of anterior proliferative 
vitreoretinopathy from the ciliary body is an effective treatment for chronic
hypotony after previous retinal detachment repair in a minority of cases. The IOP
improved in patients who tended to be younger and who had fewer previous
intraocular surgeries. Further study is indicated to evaluate long-term outcomes 
and predictors of surgical success.

PMID: 26562564   [PubMed - as supplied by publisher]


23. Retina. 2015 Nov 11. [Epub ahead of print]

REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison
Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and
Swept-Source Optical Coherence Tomography.

Barteselli G(1), Bartsch DU, Weinreb RN, Camacho N, Nezgoda JT, Marvasti AH,
Freeman WR.

Author information: 
(1)*Department of Ophthalmology, Shiley Eye Institute, University of California
San Diego, La Jolla, California; and †Genentech Inc, South San Francisco,
California.

PURPOSE: To compare the real-time visualization of vitreoretino-choroidal
structures using full-depth imaging (FDI) spectral domain optical coherence
tomography (SD-OCT) and swept-source (SS)-OCT.
METHODS: Foveal scans using both FDI SD-OCT (Heidelberg Spectralis) and SS-OCT
(Topcon Deep Range Imaging-OCT-1) were obtained in 40 normal eyes, 40 eyes with
macular pathologies, and 40 eyes with glaucoma. Full-depth imaging SD-OCT images 
were obtained by manually enhancing the vitreoretinal interface first and then
the choroid while averaging each OCT B-scan 100 times. Swept-source-OCT images
were obtained by averaging each B-scan 96 times. After masking and randomly
mixing the original OCT images, two independent physicians graded visualization
of the premacular bursa, interdigitation zone line, and chorioscleral boundary,
and also sharpness of choroidal structures.
RESULTS: A real-time full-depth image of vitreoretino-choroidal structures was
successfully achieved with FDI SD-OCT in 118 cases (98.3%) and with SS-OCT in 45 
cases (37.5%, P < 0.001). Full-depth imaging SD-OCT imaging was superior to
SS-OCT imaging in visualizing the anterior border of the premacular bursa in 109 
eyes (90.8%), with average grading of 1.63 ± 0.53 for the FDI SD-OCT and 0.39 ±
0.52 for the SS-OCT (P < 0.001). Swept-source-OCT was similar to FDI SD-OCT in
visualizing the chorioscleral boundary in 108 eyes (90.0%), with average grading 
of 1.81 ± 0.39 for the SS-OCT and 1.78 ± 0.38 for the FDI-OCT (P = 0.566). The
visualization of the interdigitation zone line was identical in the 2 imaging
instruments (P = 1.000). The sharpness of the choroidal structures was greater
with SS-OCT than with FDI-OCT (P < 0.001).
CONCLUSION: Manual double-enhancing FDI technique using SD-OCT provided a good
compromise between vitreous and retinochoroidal structures visualization in real 
time during scanning procedure. In contrast, SS-OCT imaged well details of
choroidal sublayers. Appropriate OCT technology and software should be selected
according to its application in clinical settings.

PMID: 26562563   [PubMed - as supplied by publisher]


24. Retina. 2015 Nov 11. [Epub ahead of print]

LONG-TERM RESULTS OF COMBINED AB INTERNO TRABECULOTOMY (TRABECTOME) AND
SMALL-GAUGE PARS PLANA VITRECTOMY.

Toussaint B(1), Petersen MR, Sisk RA, Riemann CD, Miller DM, Foster RE, Shaikh
AH, Khatana AH, Zink J, Greff LJ.

Author information: 
(1)Department of Ophthalmology, University of Cincinnati, Cincinnati Eye
Institute, Cincinnati, Ohio.

PURPOSE: To report outcomes of patients who have undergone combined Trabectome
and pars plana vitrectomy.
METHODS: Institutional Review Board-approved retrospective chart review of
patients seen at the Cincinnati Eye Institute before January 2014 undergoing
combined Trabectome and pars plana vitrectomy for uncontrolled glaucoma and
visually significant retina pathology. Charts were reviewed to identify changes
in intraocular pressure, visual acuity, and change in glaucoma medication
requirement up to 1 year after surgery.
RESULTS: Four patients met the inclusion criteria with 12-month follow-up, and
two of the patients were male. All patients underwent 25-gauge pars plana
vitrectomy and Trabectome surgery. Mean preoperative LogMAR visual acuity was
0.39 (20/49) and 12-month LogMAR visual acuity was 0.21 (20/32) (P = 0.06). Mean 
preoperative intraocular pressure was 17 mmHg and mean preoperative glaucoma
medication requirement was 2.5 topical medications. Twelve-month mean intraocular
pressure was 12.8 mmHg (P = 0.07), and mean topical glaucoma medication
requirement was 2.3 medications (P = 0.39). All patients were off steroids and
anti-inflammatories at the final visit. One patient developed a hyphema requiring
anterior chamber washout at 1 week. No other complications occurred.
CONCLUSION: The results suggest that combined Trabectome and pars plana
vitrectomy seems effective in the management of glaucoma in patients with
visually significant retina pathology.

PMID: 26562562   [PubMed - as supplied by publisher]


25. Retina. 2015 Nov 11. [Epub ahead of print]

Diagnostic and Therapeutic Challenges.

Phillis CA, Bourke RD, Major JC.

PMID: 26562561   [PubMed - as supplied by publisher]


26. Retina. 2015 Nov 5. [Epub ahead of print]

Reply.

Sridhar J(1), Kuriyan AE, Flynn HW Jr, Miller D.

Author information: 
(1)Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
Miller School of Medicine, Miami, Florida.

PMID: 26550993   [PubMed - as supplied by publisher]


27. Retina. 2015 Nov 4. [Epub ahead of print]

Reply.

Chen X(1).

Author information: 
(1)Department of Ophthalmology, Wuhan General Hospital of Guangzhou Command,
Wuhan, China.

PMID: 26539798   [PubMed - as supplied by publisher]


28. Retina. 2015 Nov 4. [Epub ahead of print]

Correspondence.

Soler VJ(1), Mahieu L, Matonti F, Pagot-Mathis V.

Author information: 
(1)*Unité de Rétine, Hôpital Pierre-Paul Riquet, Toulouse University Hospital,
CHU Toulouse, Toulouse, France †Laboratoire GR2DE, EA4555 UMRS1043, Centre de
Physiopathologie de Toulouse Purpan, Toulouse, France ‡Ophthalmology Department, 
Hôpital Nord, Marseille, France.

PMID: 26539797   [PubMed - as supplied by publisher]


29. Retina. 2015 Nov 4. [Epub ahead of print]

WHITE ANNULAR RETINAL DYSTROPHY WITH SEVERE GLAUCOMA: A New Autosomal Dominant
Condition.

Morizot R(1), van Schooneveld MJ, Morizot E.

Author information: 
(1)*Department of Ophthalmology, Instituto Benjamin Constant, Rio de Janeiro,
Brazil; and †Academic Medical Centre, Department of Ophthalmology, Amsterdam, the
Netherlands.

PURPOSE: To report a family with a previously unreported characteristic retinal
dystrophy and glaucoma.
METHODS: Seven family members were diagnosed with an atypical retinal dystrophy
and open-angle glaucoma with rapid evolution. Ophthalmic examination, fluorescein
angiography, color photography, optic coherence tomography, central visual-field 
examination, and ultrasonography were performed.
RESULTS: Of the 7 patients, 3 had 360° of peripheral white retina and a broad
white ring around the optic disc. In three others, it was not possible to observe
the peripheral retina, but they also showed a white retinal ring around the optic
disc. One patient showed posterior synechiae and iris neovascularization in one
eye. The 37-year-old uncle of the proband had a probably related maculopathy.
Five patients had severe glaucoma, and the youngest showed borderline intraocular
pressure.
CONCLUSION: The authors report a new dominant retinal dystrophy associated with
open-angle glaucoma. The early onset and rapidly progressive glaucoma of the
patients is atypical.

PMID: 26539796   [PubMed - as supplied by publisher]


30. Retina. 2015 Nov 3. [Epub ahead of print]

ULTRA-WIDEFIELD IMAGING OF POSTERIOR SEGMENT PATHOLOGY IN THE SETTING OF THE
BOSTON KERATOPROSTHESIS.

Kornberg DL(1), Yannuzzi NA, Klufas MA, DʼAmico DJ, Orlin A, Kiss S.

Author information: 
(1)*Department of Ophthalmology, Weill Cornell Medical College, New York, NY; and
†Retina Division, Stein Eye Institute/UCLA Medical Center, Los Angeles, CA.

PURPOSE: To evaluate the ability to visualize and document posterior segment
pathology through the Boston keratoprosthesis (KPro) using the Optos P200Tx
ultra-widefield (UWF) scanning laser ophthalmoscope.
METHODS: A retrospective chart review was conducted of patients who underwent
Boston Type I keratoprosthesis implantation and who subsequently were imaged with
an UWF system. Ultra-widefield images were reviewed to evaluate for vitreoretinal
pathology and were compared with the clinical examination.
RESULTS: In this series of 10 patients (10 eyes), 100% of vitreoretinal pathology
found on clinical examination was detectable using the Optos system. In 4 cases
(40%), UWF imaging provided superior detection of pathology compared with the
clinical examination by imaging through retroprosthetic membranes (3 cases) and
by detection of a retinal detachment (one case). In 1 case (10%), B-scan
ultrasonography was needed to characterize vitreoretinal pathology that could not
be definitively distinguished on UWF imaging and was difficult to detect on
clinical examination. Ultra-widefield imaging detected the following
vitreoretinal pathologies in KPro eyes: retinal hemorrhage, epiretinal membrane, 
retinal detachment, proliferative diabetic retinopathy, and choroidal folds.
CONCLUSION: Ultra-widefield imaging provides a high-resolution view of the
posterior pole and periphery despite the limitations of imaging through the
narrow optic of Boston Type I keratoprosthesis, and it may improve visualization 
through retroprosthetic membranes. Detection and documentation of vitreoretinal
complications in the setting of a permanent keratoprosthesis may be enhanced
using UWF imaging.

PMID: 26536101   [PubMed - as supplied by publisher]